| Consumer_Reports =| medicinenet = proton-pump_inhibitors
| rxlist =}}
Proton-pump inhibitors (PPIs) are a group of Medication|drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. They are the most potent inhibitors of acid secretion available. The group followed and has largely superseded another group of pharmacology|pharmaceuticals with similar effects, but a different mode of action, called H2-receptor antagonist|H2-receptor antagonists. These drugs are among the most widely sold drugs in the world, and are generally considered effective. The vast majority of these drugs are benzimidazole derivatives, but promising new research indicates the imidazopyridine derivatives may be a more effective means of treatment. High dose or long-term use of PPIs carry a possible increased risk of bone fractures.