Protein Threading
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Protein threading, also known as fold recognition, is a method of protein modeling (i.e. computational protein structure prediction) which is used to model those proteins which have the same Protein folding|fold as proteins of known structures, but do not have Homology_(biology)#Homology_of_sequences_in_genetics|homologous proteins with known structure.It differs from the homology modeling method of structure prediction as it (protein threading) is used for proteins which do not have their homologous protein structures deposited in the Protein Data Bank (PDB), whereas homology modeling is used for those proteins which do. Threading works by using statistical knowledge of the relationship between the structures deposited in the PDB and the Primary structure|sequence of the protein which one wishes to model.The prediction is made by threading (i.e. placing, aligning) each amino acid in the target sequence to a position in the template structure, and evaluating how well the target fits...
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