Network Motifs in Natural and Artificial Transcriptional Regulatory Networks
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We show that network motifs found in natural regulatory networks may also be found in an artificial regulatory network model created through a duplication / divergence process. It is shown that these network motifs exist more frequently in a genome created through the aforementioned process than in randomly generated genomes. These results are then com- pared with a network motif analysis of the gene expression networks of Escherichia Coli and Saccharomyces cerevisiae. In addition, it is shown that certain individual network motifs may arise directly from the duplication / divergence mechanism.